Singapore-born physician and geneticist (1962–2024) · Charis Eng · YYNN

Charis Eng

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Singapore-born physician and geneticist (1962–2024)

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The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation

scientific article published on 18 July 2006

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

scientific article published on 01 May 2002

Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein

scientific article published on December 2006

Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma

scientific article published on 16 January 2013

Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.

scientific article

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Charis Eng (17 January 1962 – 13 August 2024) was a Singaporean American physician-scientist and geneticist at the Cleveland Clinic, notable for identifying the PTEN gene. She was the chairwoman and founding director of the Genomic Medicine Institute of the Cleveland Clinic, founding director and attending clinical cancer geneticist of the...

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