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Sleep spindles are bursts of neural oscillatory activity that are generated by interplay of the thalamic reticular nucleus (TRN) and other thalamic nuclei during stage 2 NREM sleep in a frequency range of ~11 to 16 Hz (usually 12โ€“14 Hz) with a duration of 0.5 seconds or greater (usually 0.5โ€“1.5 seconds). After generation as an interaction of...