We present the transmission spectrum of the original transiting hot Jupiter HD 209458b from 2.3 to 5.1 μm as observed with the NIRCam instrument on the James Webb Space Telescope (JWST). Previous studies of HD 209458b’s atmosphere have given conflicting results on the abundance of H2O and the presence of carbon- and nitrogen-bearing species, which have significant ramifications on the inferences of the planet’s metallicity (M/H) and carbon-to-oxygen (C/O) ratio. We detect strong features of...