Background: Alcohol dependence is a major cause of morbidity and mortality worldwide and has a strong familial component. Several linkage and association studies have identified chromosomal regions and/or genes that affect alcohol consumption, notably in genes involved in the 2‐stage pathway of alcohol metabolism.Methods: Here, we use multiple regression models to test for associations and interactions between 2 alcohol‐related phenotypes and SNPs in 17 genes involved in alcohol metabolism in...