Thymic stromal lymphopoietin (TSLP) triggers dendritic cell–mediated T helper (Th) 2 inflammatory responses. A single-nucleotide polymorphism (SNP), rs3806933, in the promoter region of the TSLP gene creates a binding site for the transcription factor activating protein (AP)–1. The variant enhances AP-1 binding to the regulatory element, and increases the promoter–reporter activity of TSLP in response to polyinosinic-polycytidylic acid (poly[I:C]) stimulation in normal human bronchial...
Authors
Michishige Harada, Tomomitsu Hirota, Aya I Jodo, Yuki Hitomi, Masafumi Sakashita, Tatsuhiko Tsunoda, Takehiko Miyagawa, Satoru Doi, Makoto Kameda, Kimie Fujita, Akihiko Miyatake, Tadao Enomoto, Emiko Noguchi, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa, Yoichi Suzuki, Shigemi Yoshihara, Mitsuru Adachi, Kenji Matsumoto, Toshiharu Nakajima, Rasika A Mathias, Nicholas Rafaels, Kathleen C Barnes, Qing Ling Duan, Scott T Weiss, Yusuke Nakamura, Steven F Ziegler, Mayumi Tamari
