Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

Abstract

High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this...

Authors Timothy H T Cheng, Lynn Martin, Angela Jones, Fred Schumacher, Graham Casey, Tao Liu, Samuel Aguiar Jnr, Rodney J Scott, Qin Wang, Catherine S Healey, Rebecca Harris, Nicola Whiffin, Albert Tenesa

Ratings 0

Lists 0

Abstract

Reading

Instance of

Author

Published in

Subject

License

References