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Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity
BAK core dimers bind lipids and can be bridged by them
Physiological restraint of Bak by Bcl-xL is essential for cell survival
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes
Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax