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Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways
