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Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function
Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways
