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Margaret A. Phillips
Works
Chemical genetics of Plasmodium falciparum
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scientific article (publication date: 20 May 2010)
Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds
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scientific article
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
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scientific article published on 20 April 2021
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice
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scientific article published on April 2009
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif
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scientific article
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.
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scientific article published on 04 June 2008
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
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scientific article published on 30 June 2015
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase
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scientific article
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
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scientific article
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
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scientific article
Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265
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scientific article published on 13 November 2018
Malaria
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scholarly article by Margaret A. Phillips et al published 3 August 2017 in Nature Reviews Disease Primers